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AIT Bioscience’s Solution to a Tricky Peptide

AIT Bioscience’s Solution to a Tricky Peptide Triptorelin LC-MS/MS Case Study Triptorelin is used for the treatment of estrogen-dependent conditions, certain cancers, and assisted reproduction in livestock. In the treatment of advanced prostate cancer, it is a gonadotropin-releasing hormone agonist marketed by Watson Pharmaceuticals as Trelstar and typically administered as an intramuscular injection. Sequence: pGlu-His-Trp-Ser-Tyr-DTrp-Leu-Arg-Pro-Gly-NH2 … read the full article » »

Categories: LC-MS/MS Methods

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Bioanalytical Considerations for your Dermal Pharmaceutical Programs

Bioanalytical Considerations for your Dermal Pharmaceutical Programs Does your drug require sustained release or suffer from first pass metabolism losses?   Have you considered transdermal delivery via cream gel or patch?   How does bioanalysis differ for oral or dermal delivery?   The dermis is the largest organ of the human body and provides a … read the full article » »

Categories: LC-MS/MS Methods, Screening Assay, Special Topics

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Bioanalytical Method Development Strategy for Proteins

By: Michael Schneider   A bioanalytical method development strategy is presented for quantitative protein analysis by LC-MS/MS when no capture antibody is available for bioanalytical sample clean-up or enrichment. A robust quantitative method for protein therapeutics can be quickly developed and performed in less than a day by using the Perfinity Workstation for on-line sample … read the full article » »

Categories: LC-MS/MS Methods, Proteins and LC-MS/MS

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