AIT Bioscience’s Solution to a Tricky Peptide - AIT BioscienceAIT Bioscience

AIT Bioscience’s Solution to a Tricky Peptide

AIT Bioscience’s Solution to a Tricky Peptide

Triptorelin LC-MS/MS Case Study

 

Triptorelin is used for the treatment of estrogen-dependent conditions, certain cancers, and assisted
reproduction in livestock. In the treatment of advanced prostate cancer, it is a gonadotropin-releasing hormone agonist marketed by Watson Pharmaceuticals as Trelstar and typically administered as an intramuscular injection.

 

Sequence:

 

pGlu-His-Trp-Ser-Tyr-DTrp-Leu-Arg-Pro-Gly-NH2

 

Project Challenges:

 

  • Multiple methods development problems (sticky, chemical instability, and low recovery)
  • High sensitivity method required (50 pg/mL for decapeptide)
  • Literature method initially seemed workable but became unreliable due to sample turbidity and
    system shutdown

 

To see how our team of experts tackled these challenges, download our case study.

 

Contact us today to see how using an expert contract bioanalytical lab can bring value to your  programs.

 

 

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Categories: LC-MS/MS Methods.


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