List of Assays

Finding a Bioanalytical PK assay that meets 100% of your study’s needs can be a challenge. Often, tweaks to a variety of parameters such as the LLOQ, dynamic range, anticoagulant and species are necessary, requiring lab time before subject enrollment. AITB validates assays efficiently and accurately by employing its vast experience with small molecules, large biotherapeutics and a variety of methodologies ranging from mass spectrometry to ligand binding.

 

Integrating assay development experience, industry leading quality systems, and efficient lab operations, we can deliver QA weeks ahead of industry standards. We work collaboratively with clinical and Tox sites to ensure studies flow smoothly.

 

Can’t find what you’re looking for in this list? Check out a list of assays under development.

 

Have a specific question?  Call or email Bo Kowalczyk, VP of Business Development, 1-708-698-1090, Bo@aitbioscience.com

PK Assays

Analyte(s) BAM Range BAM Validation Level Anticoagulant Species Matrix
Ritonavir 10.0-10,000 Full Regulatory K2 EDTA Human Plasma
Ondansetron 0.250 – 250 Full Regulatory K2 EDTA Human Plasma
Melatonin 1.00-1,000 Full Regulatory NA Human Saliva
Simvastatin and Simvastatin Hydroxy Acid 50.0-50,000 Full Regulatory K2 EDTA Human Plasma
 Fentanyl 5.00-5,000 Full Regulatory K2 EDTA Human Plasma
Morphine, Oxycodone and Morphine-6-Glucuronide 0.200-50.0, 0.400-100 Full Regulatory K2 EDTA Human Plasma
Ketoprofen 1.00-1,000 Full Regulatory K2 EDTA Human Acidified Plasma (30mg-mL Citric Acid)
 (R)-Methadone and (S)-Methadone 1.00-1,000 Full Regulatory K2 EDTA Human Plasma
 Nordiazepam 0.500-500 Full Regulatory K2 EDTA Human Plasma
Clorazepate 0.500-500 Full Regulatory K2 EDTA Human Plasma
Diclofenac 0.100-1,000 Full Regulatory K2 EDTA Human Plasma
Atorvastatin, 2-Hydroxyatorvastatin, and 4-Hydroxyatorvastatin 50.0-50,000, 20.0-20,000 Full Regulatory K2 EDTA Human Plasma
 Hydrocodone, Hydromorphone,  Norhydrocodone and  Acetaminophen 0.100-100, 50.0-50,000 Full Regulatory K2 EDTA Human Plasma
Rosuvastatin 0.100-100 Full Regulatory K2 EDTA Human Plasma
Pravastatin 0.100-100 Full Regulatory K2 EDTA Human Plasma
 (R)-Amphetamine and (S)-Amphetamine 0.200-200 Full Regulatory K2 EDTA Human Plasma
 Ropivacaine 1.00-1,000 Full Regulatory K2 EDTA Human Plasma Ultrafiltrate
Ropivacaine 1.00-1,000 Full Regulatory K2 EDTA Human Plasma
 Fentanyl 5.00-5,000 Full Regulatory K2 EDTA Human Plasma
Ethinyl Estradiol and Norethindrone 7.50-7,500, 100-100,000 Full Regulatory K2 EDTA Human Plasma
Caffeine metabolites 1MX and AFMU 100-100,000 Full Regulatory NA Human Urine, Charcoal Stripped (2x)
 Isradipine 0.100- 100 Full Regulatory K2 EDTA Human Plasma
 Metformin 5.00-5,000 Full Regulatory K2 EDTA Human Plasma
Anti-Insulin Antibodies 100 – 1,000 Full Regulatory NA Human Serum

 

Biomarkers

Marker Range
bST (bovine somatotropin) 1.25-50 ng/mL
CA 19-9 200-0.274 U/mL
CAIX 500-31.3 pg/mL
C-peptide 20-1200 pM/L
CRP 27.6-49608 pg/mL
GLP-1 NA
Haptoglobin NA
IFN lamda 50-50,000 pg/mL
IGF1 (insulin-like growth factor 1) 0.312-20 ng/mL
IgG2 antibodies 0.056-10,000 ng/mL
IL-10 0.68-233 pg/mL
IL-12 25-3,200 pg/mL
IL-12p70 1.22-315 pg/mL
IL-17 9.32-3653 pg/mL
IL-6 1.58-488 pg/mL
IL-8 1.13-375 pg/mL
Lipopolysaccharide Binding Protein NA
Myeloperoxidase 0.312-20 ng/mL
Serum Amyloid A 54.1-137,972 pg/mL
TGF beta1 30-2000 pg/mL
TNF alpha 0.69-248 pg/mL
TNF-alph, IL-1 beta, IL-2, IL-12p70 NA
VEGF 7.70-784 pg/mL